Selected article for: "activity compound and acute toxicity"
Author: Wang, Li-Jun; Geng, Chang-An; Ma, Yun-Bao; Luo, Jie; Huang, Xiao-Yan; Chen, Hao; Zhou, Ning-Jia; Zhang, Xue-Mei; Chen, Ji-Jun
Title: Design, synthesis, and molecular hybrids of caudatin and cinnamic acids as novel anti-hepatitis B virus agents
  • Cord-id: 73ielqis
  • Document date: 2012_5_25
    • ID: 73ielqis
    Snippet: Forty-six conjugated derivatives of caudatin with substituted cinnamic acids were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Most of the derivatives exhibited potent anti-HBV activity, especially inhibiting the HBV DNA replication with the IC(50) values from 2.44 to 22.89 μΜ. Compound 18 showed significant activity against the secretion of HBsAg, HBeAg, and HBV DNA replication with IC(50) values of 5.52, 5.52, 2.44 μΜ, respectively, and h
    Document: Forty-six conjugated derivatives of caudatin with substituted cinnamic acids were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Most of the derivatives exhibited potent anti-HBV activity, especially inhibiting the HBV DNA replication with the IC(50) values from 2.44 to 22.89 μΜ. Compound 18 showed significant activity against the secretion of HBsAg, HBeAg, and HBV DNA replication with IC(50) values of 5.52, 5.52, 2.44 μΜ, respectively, and had good safety (LD(50) > 1250 mg/kg) according to the acute toxicity study. Preliminary mechanism investigation suggested that compound 18 exerted antivirus effects via interfering HBV X promoter and enhancer I to influence HBV transcriptions.

    Search related documents:
    Co phrase search for related documents
    • action mechanism and liver failure: 1
    • action mechanism and liver specific: 1, 2
    • action mechanism and low cytotoxicity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • action mechanism and luciferase activity: 1
    • action mechanism and luciferase gene: 1, 2
    • action mechanism and luciferase reporter: 1, 2, 3, 4, 5, 6
    • action mechanism and luciferase reporter assay: 1, 2
    • action mechanism and luciferase reporter gene assay: 1
    • action mechanism and magnetic resonance: 1, 2, 3, 4, 5, 6, 7, 8
    • action mechanism elucidate and luciferase reporter: 1
    • action mechanism elucidate and magnetic resonance: 1
    • active compound and acute toxicity: 1, 2, 3, 4, 5
    • active compound and low cytotoxicity: 1, 2
    • active compound and magnetic resonance: 1, 2, 3, 4
    • acute toxicity and liver failure: 1, 2, 3
    • acute toxicity and magnetic resonance: 1, 2, 3, 4, 5
    • adefovir dipivoxil and low cytotoxicity: 1
    • liver failure and magnetic resonance: 1, 2, 3, 4, 5
    • liver specific and luciferase reporter: 1