Author: Edison Ong; Mei U Wong; Anthony Huffman; Yongqun He
Title: COVID-19 coronavirus vaccine design using reverse vaccinology and machine learning Document date: 2020_3_21
ID: ld0vo1rl_11
Snippet: However, these predicted non-structural proteins (nasp3, 3CL-pro, nsp8, nsp9, and nsp10) 246 are not part of the viral structural particle, and all the current SARS/MERS/COVID-19 vaccine 247 studies target the structural (S/M/N) proteins. Although structural proteins are commonly used as 248 viral vaccine candidates, non-structural proteins correlates to vaccine protection. The non-249 structural protein NS1 was found to induce protective immunit.....
Document: However, these predicted non-structural proteins (nasp3, 3CL-pro, nsp8, nsp9, and nsp10) 246 are not part of the viral structural particle, and all the current SARS/MERS/COVID-19 vaccine 247 studies target the structural (S/M/N) proteins. Although structural proteins are commonly used as 248 viral vaccine candidates, non-structural proteins correlates to vaccine protection. The non-249 structural protein NS1 was found to induce protective immunity against the infections by 250 flaviviruses 36 . Since NS1 is not part of the virion, antibodies against NS1 have no neutralizing 251 activity but some exhibit complement-fixing activity 37 . However, passive transfer of anti-NS1 252 antibody or immunization with NS1 conferred protection 38 . Anti-NS1 antibody could also reduce 253 might induce cell-mediated or humoral immunity necessary to prevent viral invasion and/or 262 replication. None of the non-structural proteins have been evaluated as vaccine candidates, and the 263 feasibilit of these proteins as vaccine targets are subject to further experimental verification. 264
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