Selected article for: "cell cell and host cell entry"
Author: Edison Ong; Mei U Wong; Anthony Huffman; Yongqun He
Title: COVID-19 coronavirus vaccine design using reverse vaccinology and machine learning
  • Document date: 2020_3_21
    • ID: ld0vo1rl_5
    Snippet: The Vaxign RV analysis predicted six SARS-CoV-2 proteins (S protein, nsp3, 3CL-PRO, 148 and nsp8-10) as adhesive proteins (Table 3) . Adhesin plays a critical role in the virus adhering to 149 the host cell and facilitating the virus entry to the host cell 25 , which has a significant association 150 with the vaccine-induced protection 26 . In SARS-CoV-2, S protein was predicted to be adhesin, 151 matching its primary role in virus entry. The str.....
    Document: The Vaxign RV analysis predicted six SARS-CoV-2 proteins (S protein, nsp3, 3CL-PRO, 148 and nsp8-10) as adhesive proteins (Table 3) . Adhesin plays a critical role in the virus adhering to 149 the host cell and facilitating the virus entry to the host cell 25 , which has a significant association 150 with the vaccine-induced protection 26 . In SARS-CoV-2, S protein was predicted to be adhesin, 151 matching its primary role in virus entry. The structure of SARS-CoV-2 S protein was determined 27 152 and reported to contribute to the host cell entry by interacting with the angiotensin-converting 153 enzyme 2 (ACE2) 28 . Besides S protein, the other five predicted adhesive proteins were all non-154 structural proteins. In particular, nsp3 is the largest non-structural protein of SARS-CoV-2 155 comprises various functional domains 29 . 156 157 Three adhesin proteins were predicted to induce strong protective immunity 158

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