Author: Collin D. Heer; Daniel J. Sanderson; Yousef M.O. Alhammad; Mark S. Schmidt; Samuel A.J. Trammell; Stanley Perlman; Michael S. Cohen; Anthony R. Fehr; Charles Brenner
Title: Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity Document date: 2020_4_18
ID: 033phqmd_13
Snippet: Specifically, in the ferret, PARPs 4, 5, 9, 13, 14 and 15 were all more than 4-fold induced with significant but lesser induction of PARPs 7 and 11. In ferret tracheas, it Table 1 ). Depicted are volcano plot (normalized relative expression versus -log(P) with respect to noninfected A) human A549 lung cancer cells B) NHBE cells, C) ferret trachea, and D) lung of a diseased COVID-19 patient. Further information is available in supplementary Inform.....
Document: Specifically, in the ferret, PARPs 4, 5, 9, 13, 14 and 15 were all more than 4-fold induced with significant but lesser induction of PARPs 7 and 11. In ferret tracheas, it Table 1 ). Depicted are volcano plot (normalized relative expression versus -log(P) with respect to noninfected A) human A549 lung cancer cells B) NHBE cells, C) ferret trachea, and D) lung of a diseased COVID-19 patient. Further information is available in supplementary Information 2-5.
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