Selected article for: "data set and gene expression"
Author: Collin D. Heer; Daniel J. Sanderson; Yousef M.O. Alhammad; Mark S. Schmidt; Samuel A.J. Trammell; Stanley Perlman; Michael S. Cohen; Anthony R. Fehr; Charles Brenner
Title: Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity
  • Document date: 2020_4_18
    • ID: 033phqmd_18
    Snippet: NAD biosynthetic gene changes were also conserved in vivo: NMRK1 expression, indicating capacity for NR salvage, was elevated with statistical significance in ferret trachea, and NAMPT expression, indicating capacity for NAM salvage, was elevated with statistical significance in human lung. NMRK1 and NMRK2 transcripts were additionally elevated in the human patient data set and NAMPT transcript was elevated in the ferret infection data set withou.....
    Document: NAD biosynthetic gene changes were also conserved in vivo: NMRK1 expression, indicating capacity for NR salvage, was elevated with statistical significance in ferret trachea, and NAMPT expression, indicating capacity for NAM salvage, was elevated with statistical significance in human lung. NMRK1 and NMRK2 transcripts were additionally elevated in the human patient data set and NAMPT transcript was elevated in the ferret infection data set without meeting . CC-BY-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.17.047480 doi: bioRxiv preprint criteria for statistical significance. Further data on transcriptomic alterations to NAD synthesis in all four data sets are provided in Supplementary Information 6.

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