Author: Collin D. Heer; Daniel J. Sanderson; Yousef M.O. Alhammad; Mark S. Schmidt; Samuel A.J. Trammell; Stanley Perlman; Michael S. Cohen; Anthony R. Fehr; Charles Brenner
Title: Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity Document date: 2020_4_18
ID: 033phqmd_23
Snippet: These results suggest that boosting NAD + levels by augmenting cytosolic synthesis rather than reducing nuclear NAD + consumption may be a preferable approach to supporting PARP10 activity in cells. . PARP10 activity is stimulated by NAMPT activation but not PARP1,2 inhibition. PARP10 and GFP-expressing HEK293 cells were used to show that veliparib and SBI-797812 differ in their ability to promote the autoMARylated form of PARP10. A) Western blot.....
Document: These results suggest that boosting NAD + levels by augmenting cytosolic synthesis rather than reducing nuclear NAD + consumption may be a preferable approach to supporting PARP10 activity in cells. . PARP10 activity is stimulated by NAMPT activation but not PARP1,2 inhibition. PARP10 and GFP-expressing HEK293 cells were used to show that veliparib and SBI-797812 differ in their ability to promote the autoMARylated form of PARP10. A) Western blot and B) quantification indicate that the NAMPT activator, SBI-797812 promotes PARP10 activity whereas the PARP1,2 inhibitor does not promote PARP10 activity.
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