Author: Collin D. Heer; Daniel J. Sanderson; Yousef M.O. Alhammad; Mark S. Schmidt; Samuel A.J. Trammell; Stanley Perlman; Michael S. Cohen; Anthony R. Fehr; Charles Brenner
Title: Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity Document date: 2020_4_18
ID: 033phqmd_42
Snippet: Though the focus of this preclinical work is prevention, we note that innate immune responses to CoV infection, like other inflammatory responses, are potentially pathological if infection is not controlled. COVID-19 patients with acute respiratory distress syndrome experience a cytokine storm that features high level circulation of inflammatory cytokines (Mehta et al., 2020) . Interestingly, in a small placebo-controlled clinical trial designed .....
Document: Though the focus of this preclinical work is prevention, we note that innate immune responses to CoV infection, like other inflammatory responses, are potentially pathological if infection is not controlled. COVID-19 patients with acute respiratory distress syndrome experience a cytokine storm that features high level circulation of inflammatory cytokines (Mehta et al., 2020) . Interestingly, in a small placebo-controlled clinical trial designed to address the oral safety and activity of Niagen NR in older men, it was discovered that 1 gram of NR per day depresses levels of IL-6, IL-5, IL-2 and tumor necrosis factor alpha (Elhassan et al., 2019) , suggesting the possibility that Niagen and other NAD boosters may also be tested for safety, control of cytokine storm, and modulation of COVID-19 disease in patients.
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