COVID-19 clinical characteristics, and sex-specific risk of mortality: Systematic Review and Meta-analysis

Mohammad Javad Nasiri; Sara Haddadi; Azin Tahvildari; Yeganeh Farsi; Mahta Arbabi; Saba Hasanzadeh; Parnian Jamshidi; Mukunthan Murthi; Mehdi Mirsaeidi

is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.03.24.20042903 doi: medRxiv preprint minimum and maximum periods of 14 and 21 days respectively. The effects and summaries 277 calculated using a random-effects model weighted by the study population is shown in Figure 2 . were the most common imaging modalities used for the diagnosis. The pooled sensitivity of CT-288 san for COVID19 was 79.3%. We found 20.7% of the patients with confirmed RT-PCR who had 289 normal chest CT-Scan suggesting that a normal chest CT-scan cannot rule out the disease in 290 patients who are highly suspicious for COVID-19. Several complications were seen due to 291 COVID-19. Among these, acute hepatitis was the most common one occurring in 13.3% of cases, 292 followed by cardiac injury with troponin levels greater than 28 pg/ml seen in 12.4%. The pooled 293 mortality rate of these patients was 6.6%. We detected several factors contributing to a worse 294 outcome including old age, male sex, presence of underlying diseases and some abnormal 295 laboratory finding such as high level of D-Dimer. Although there was not any significant difference 296 . CC-BY 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.