Author: Chatzileontiadou, Demetra S.M.; Szeto, Christopher; Jayasinghe, Dhilshan; Gras, Stephanie
Title: Protein purification and crystallization of HLA-A*02:01 in complex with SARS-CoV-2 peptides Cord-id: 5g1ute03 Document date: 2021_6_9
ID: 5g1ute03
Snippet: Understanding T cell responses requires identifying viral peptides presented by Human Leukocyte Antigens (HLA). X-ray crystallography can be used to visualize their presentation. This protocol describes the expression, purification, and crystallization of HLA-A*02:01, one of the most frequent HLA in the global population in complex with peptides derived from the SARS-CoV-2 Nucleocapsid protein. This protocol can be applied to different HLA-class I molecules bound to other peptides.
Document: Understanding T cell responses requires identifying viral peptides presented by Human Leukocyte Antigens (HLA). X-ray crystallography can be used to visualize their presentation. This protocol describes the expression, purification, and crystallization of HLA-A*02:01, one of the most frequent HLA in the global population in complex with peptides derived from the SARS-CoV-2 Nucleocapsid protein. This protocol can be applied to different HLA-class I molecules bound to other peptides.
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