Author: Edison Ong; Mei U Wong; Anthony Huffman; Yongqun He
Title: COVID-19 coronavirus vaccine design using reverse vaccinology and machine learning Document date: 2020_3_21
ID: ld0vo1rl_3
Snippet: In recent years, the development of vaccine design has been revolutionized by the reverse 90 vaccinology (RV), which aims to first identify promising vaccine candidate through 91 bioinformatics analysis of the pathogen genome. RV has been successfully applied to vaccine 92 discovery for pathogens such as Group B meningococcus and led to the license Bexsero 93 vaccine 12 . Among current RV prediction tools 13,14 , Vaxign is the first web-based RV .....
Document: In recent years, the development of vaccine design has been revolutionized by the reverse 90 vaccinology (RV), which aims to first identify promising vaccine candidate through 91 bioinformatics analysis of the pathogen genome. RV has been successfully applied to vaccine 92 discovery for pathogens such as Group B meningococcus and led to the license Bexsero 93 vaccine 12 . Among current RV prediction tools 13,14 , Vaxign is the first web-based RV program 15 94 and has been used to successfully predict vaccine candidates against different bacterial and viral 95 pathogens [16] [17] [18] . Recently we have also developed a machine learning approach called Vaxign-ML 96 to enhance prediction accuracy 19 . 97
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