Author: Dan Zhang; Rui Guo; Lei Lei; Hongjuan Liu; Yawen Wang; Yili Wang; Tongxin Dai; Tianxiao Zhang; Yanjun Lai; Jingya Wang; Zhiqiang Liu; Aili He; Michael O'Dwyer; Jinsong Hu
Title: COVID-19 infection induces readily detectable morphological and inflammation-related phenotypic changes in peripheral blood monocytes, the severity of which correlate with patient outcome Document date: 2020_3_26
ID: nlavfnpt_32
Snippet: Here we report our findings in 28 patients with confirmed COVID-19 infection with varying degrees of severity. We identified a distinct change in the morphology and function of monocytes/macrophages that was predictive of severity of disease, likelihood of ICU admission, length of hospital stay and full recovery. These monocytes were characterized by a shift in forward scatter on flow cytometry as well as a relative increase in intermediate and n.....
Document: Here we report our findings in 28 patients with confirmed COVID-19 infection with varying degrees of severity. We identified a distinct change in the morphology and function of monocytes/macrophages that was predictive of severity of disease, likelihood of ICU admission, length of hospital stay and full recovery. These monocytes were characterized by a shift in forward scatter on flow cytometry as well as a relative increase in intermediate and non-classical monocytes. These FSC-high monocytes are CD14 + CD16 + and express macrophage markers CD68 + CD80 + CD163 + CD206 + , which represent an inflammatory monocyte subset not typically seen in healthy controls. author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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