Author: Bosc, Jean-Jacques; Latxague, Laurent; Léger, Jean-Michel; Balzarini, Jan; Forfar, Isabelle; Jarry, Christian; Guillon, Jean
Title: Synthesis and in vitro cytostatic activity of new β-d-arabino furan[1′,2′:4,5]oxazolo- and arabino-pyrimidinone derivatives Cord-id: 5mtmkpfv Document date: 2009_10_29
ID: 5mtmkpfv
Snippet: A series of nucleoside derivatives was obtained via heteroatom annulation of the amino oxazoline of d-(−)-arabinose. Unequivocal proofs for the stereostructure of some new arabinosyl pyrimidinone derivatives were obtained by X-ray structure analysis. These newly synthesized compounds were then evaluated for their cytostatic activity against murine leukemia (L1210), and human T-lymphocytes (Molt 4/C8 and CEM). Of all the compounds in the series, the protected silylated tricyclic fused pyrimidin
Document: A series of nucleoside derivatives was obtained via heteroatom annulation of the amino oxazoline of d-(−)-arabinose. Unequivocal proofs for the stereostructure of some new arabinosyl pyrimidinone derivatives were obtained by X-ray structure analysis. These newly synthesized compounds were then evaluated for their cytostatic activity against murine leukemia (L1210), and human T-lymphocytes (Molt 4/C8 and CEM). Of all the compounds in the series, the protected silylated tricyclic fused pyrimidinone 10 showed the most significant antitumor activity against murine leukemia L1210 (IC(50) = 6 μM), and human T-lymphocytes cells Molt 4/C8 (IC(50) = 7.9 μM) and CEM/0 cell lines (IC(50) = 7.5 μM). None of the compounds exhibited significant antiviral inhibitory activities.
Search related documents:
Co phrase search for related documents- active find and low activity: 1
- activity show and low activity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
Co phrase search for related documents, hyperlinks ordered by date