Author: Zuckerman, Neta S.; Fleishon, Shay; Bucris, Efrat; Bar-Ilan, Dana; Linial, Michal; Bar-Or, Itay; Indenbaum, Victoria; Weil, Merav; Lustig, Yaniv; Mendelson, Ella; Mandelboim, Michal; Mor, Orna; Zuckerman, Neta
Title: A Unique SARS-CoV-2 Spike Protein P681H Variant Detected in Israel Cord-id: 2lvqv0q7 Document date: 2021_6_8
ID: 2lvqv0q7
Snippet: The routine detection, surveillance, and reporting of novel SARS-CoV-2 variants is crucial, as these threaten to hinder global vaccination efforts. Herein we report a novel local variant with a non-synonymous mutation in the spike (S) protein P681H. This local Israeli variant was not associated with a higher infection rate or higher prevalence. Furthermore, the local variant was successfully neutralized by sera from fully vaccinated individuals at a comparable level to the B.1.1.7 variant and an
Document: The routine detection, surveillance, and reporting of novel SARS-CoV-2 variants is crucial, as these threaten to hinder global vaccination efforts. Herein we report a novel local variant with a non-synonymous mutation in the spike (S) protein P681H. This local Israeli variant was not associated with a higher infection rate or higher prevalence. Furthermore, the local variant was successfully neutralized by sera from fully vaccinated individuals at a comparable level to the B.1.1.7 variant and an Israel wild-type strain. While it is not a variant of concern, routine monitoring by sequencing is still required.
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