Author: De Sanctis, Juan Bautista; GarcÃa, Alexis Hipólito; Moreno, Dolores; Hajduch, Marián
Title: Coronavirus infection: An immunologists' perspective Cord-id: 4hclmvpk Document date: 2021_4_7
ID: 4hclmvpk
Snippet: Coronavirus infections are frequent viral infections in several species. As soon as the severe acute respiratory syndrome (SARS) appeared in the early 2000s, most of the research focused on pulmonary disease. However, disorders in immune response and organ dysfunctions have been documented. Elderly individuals with comorbidities exhibit worse outcomes in all the coronavirus that cause SARS. Disease severity in SARSâ€CoVâ€2 infection is related to severe inflammation and tissue injury, and effe
Document: Coronavirus infections are frequent viral infections in several species. As soon as the severe acute respiratory syndrome (SARS) appeared in the early 2000s, most of the research focused on pulmonary disease. However, disorders in immune response and organ dysfunctions have been documented. Elderly individuals with comorbidities exhibit worse outcomes in all the coronavirus that cause SARS. Disease severity in SARSâ€CoVâ€2 infection is related to severe inflammation and tissue injury, and effective immune response against the virus is still under analysis. ACE2 receptor expression and polymorphism, age, gender and immune genetics are factors that also play an essential role in patients' clinical features and immune responses and have been partially discussed. The present report aims to review the physiopathology of SARSâ€CoVâ€2 infection and propose new research topics to understand the complex mechanisms of viral infection and viral clearance.
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