Selected article for: "domain host receptor and host receptor"

Author: Röltgen, Katharina; Wirz, Oliver F.; Stevens, Bryan A.; Powell, Abigail E.; Hogan, Catherine A.; Najeeb, Javaria; Hunter, Molly; Sahoo, Malaya K.; Huang, ChunHong; Yamamoto, Fumiko; Manalac, Justin; Otrelo-Cardoso, Ana R.; Pham, Tho D.; Rustagi, Arjun; Rogers, Angela J.; Shah, Nigam H.; Blish, Catherine A.; Cochran, Jennifer R.; Nadeau, Kari C.; Jardetzky, Theodore S.; Zehnder, James L.; Wang, Taia T.; Kim, Peter S.; Gombar, Saurabh; Tibshirani, Robert; Pinsky, Benjamin A.; Boyd, Scott D.
Title: SARS-CoV-2 Antibody Responses Correlate with Resolution of RNAemia But Are Short-Lived in Patients with Mild Illness
  • Cord-id: 2mr65igk
  • Document date: 2020_8_17
  • ID: 2mr65igk
    Snippet: SARS-CoV-2-specific antibodies, particularly those preventing viral spike receptor binding domain (RBD) interaction with host angiotensin-converting enzyme 2 (ACE2) receptor, could offer protective immunity, and may affect clinical outcomes of COVID-19 patients. We analyzed 625 serial plasma samples from 40 hospitalized COVID-19 patients and 170 SARS-CoV-2-infected outpatients and asymptomatic individuals. Severely ill patients developed significantly higher SARS-CoV-2-specific antibody response
    Document: SARS-CoV-2-specific antibodies, particularly those preventing viral spike receptor binding domain (RBD) interaction with host angiotensin-converting enzyme 2 (ACE2) receptor, could offer protective immunity, and may affect clinical outcomes of COVID-19 patients. We analyzed 625 serial plasma samples from 40 hospitalized COVID-19 patients and 170 SARS-CoV-2-infected outpatients and asymptomatic individuals. Severely ill patients developed significantly higher SARS-CoV-2-specific antibody responses than outpatients and asymptomatic individuals. The development of plasma antibodies was correlated with decreases in viral RNAemia, consistent with potential humoral immune clearance of virus. Using a novel competition ELISA, we detected antibodies blocking RBD-ACE2 interactions in 68% of inpatients and 40% of outpatients tested. Cross-reactive antibodies recognizing SARS-CoV RBD were found almost exclusively in hospitalized patients. Outpatient and asymptomatic individuals’ serological responses to SARS-CoV-2 decreased within 2 months, suggesting that humoral protection may be short-lived.

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