Author: Brochhausen, Christoph; Schmitt, Volker H; Planck, Constanze N E; Rajab, Taufiek K; Hollemann, David; Tapprich, Christine; Krämer, Bernhard; Wallwiener, Christian; Hierlemann, Helmut; Zehbe, Rolf; Planck, Heinrich; Kirkpatrick, C James
Title: Current strategies and future perspectives for intraperitoneal adhesion prevention. Cord-id: 24hqo4rj Document date: 2012_1_1
ID: 24hqo4rj
Snippet: INTRODUCTION The formation of peritoneal adhesions still is a relevant clinical problem after abdominal surgery. Until today, the most important clinical strategies for adhesion prevention are accurate surgical technique and the physical separation of traumatized serosal areas. Despite a variety of barriers which are available in clinical use, the optimal material has not yet been found. DISCUSSION Mesothelial cells play a crucial physiological role in friction less gliding of the serosa and the
Document: INTRODUCTION The formation of peritoneal adhesions still is a relevant clinical problem after abdominal surgery. Until today, the most important clinical strategies for adhesion prevention are accurate surgical technique and the physical separation of traumatized serosal areas. Despite a variety of barriers which are available in clinical use, the optimal material has not yet been found. DISCUSSION Mesothelial cells play a crucial physiological role in friction less gliding of the serosa and the maintenance of anantiadhesive surface. The formation of postoperative adhesions results from a cascade of events and is regulated by various cellular and humoral factors. Therefore, optimization or functionalization of barrier materials by developments interacting with this cascade on a structural or pharmacological level could give an innovative input for future strategies in peritoneal adhesion prevention. For this purpose, the proper understanding of the formal pathogenesis of adhesion formation is essential. Based on the physiology of the serosa and the pathophysiology of adhesion formation, the available barriers in current clinical practice as well as new innovations are discussed in the present review.
Search related documents:
Co phrase search for related documents- abdominal surgery and adhesion formation pathophysiology: 1
- abdominal surgery and adhesion prevention: 1, 2, 3
Co phrase search for related documents, hyperlinks ordered by date