Author: Almaghaslah, Dalia; Kandasamy, Geetha; Almanasef, Mona; Vasudevan, Rajalakshimi; Chandramohan, Sriram
Title: Review on the coronavirus disease (COVIDâ€19) pandemic: its outbreak and current status Cord-id: 2rw57lio Document date: 2020_8_4
ID: 2rw57lio
Snippet: BACKGROUND: In late December 2019 and on 1(st) January 2020, the coronavirus (COVIDâ€19) infecting humans was first identified in Wuhan, Hubei Province, China. Later cases have also been confirmed worldwide. Coronaviruses are RNA viruses that are phenotypically and genotypically diverse. Globally, as of 6(th) April 2020, laboratory confirmed cases of COVIDâ€19 reported to the World Health Organization (WHO) amounted to 1,211,214, including 67,666 deaths. AIM: In the current study, we performed
Document: BACKGROUND: In late December 2019 and on 1(st) January 2020, the coronavirus (COVIDâ€19) infecting humans was first identified in Wuhan, Hubei Province, China. Later cases have also been confirmed worldwide. Coronaviruses are RNA viruses that are phenotypically and genotypically diverse. Globally, as of 6(th) April 2020, laboratory confirmed cases of COVIDâ€19 reported to the World Health Organization (WHO) amounted to 1,211,214, including 67,666 deaths. AIM: In the current study, we performed a literature review on coronavirus outbreak to summarize details about the pathogenesis, epidemiology, diagnosis, and the management strategies for the disease control. PATHOGENESIS: Coronaviruses are tremendously precise and mature only in differentiated respiratory epithelial cells, as seen in both organ cultures as well as human volunteers. This virus will cause the antiviral Tâ€cell response to be erratic, owing to the Tâ€cell apoptosis activation, triggering the immune system to collapse. TRANSMISSION: The understanding of the transmission of COVIDâ€19 risk is incomplete. The transmission mainly occurs through the respiratory droplets once an infected person sneezes, like the spread of flu and other respiratory infectious agents. CLINICAL PRESENTATION: Presentations of COVIDâ€19 includes fever, cough, shortness of breath, malaise and respiratory distress. TREATMENT: There have been no approved vaccines available for COVIDâ€19 until today. The Ministry of Science and Technology in the People’s Republic of China declared three potential antiâ€viral medicines suitable for treating COVIDâ€19. Those three medicines are, namely, favilavir, chloroquine phosphate, and remdesivir. Hydroxychloroquine combined with azithromycin enhances the reduction of the viral load in COVIDâ€19 patients. CONCLUSION: The corona virus transmits quicker than its two predecessors the MERSâ€CoV and SARSâ€CoV, but has reduced casualty. The global effects of this latest pandemic are still unclear. Nevertheless, considering that so far no vaccine has been available; preventive approaches are the best way to fight against the virus.
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