Selected article for: "antibody expression and transgene expression"

Author: Tan, Tiong Kit; Gamlen, Toby P E; Rijal, Pramila; Townsend, Alain R; Gill, Deborah R; Hyde, Stephen C
Title: Lung-targeting lentiviral vector for passive immunisation against influenza
  • Cord-id: 2rxqg4qo
  • Document date: 2020_9_3
  • ID: 2rxqg4qo
    Snippet: When recombinant simian immunodeficiency virus (SIV) is pseudotyped with the F and HN glycoproteins from murine respiratory Sendai virus (rSIV.F/HN), it provides efficient lung cell targeting and lifelong transgene expression in the murine airways. We have shown that a single dose of rSIV.F/HN can direct stable expression of neutralising antibody against influenza in the murine airways and systemic circulation, and protects mice against two different influenza strains in lethal challenge experim
    Document: When recombinant simian immunodeficiency virus (SIV) is pseudotyped with the F and HN glycoproteins from murine respiratory Sendai virus (rSIV.F/HN), it provides efficient lung cell targeting and lifelong transgene expression in the murine airways. We have shown that a single dose of rSIV.F/HN can direct stable expression of neutralising antibody against influenza in the murine airways and systemic circulation, and protects mice against two different influenza strains in lethal challenge experiments. These data suggest that rSIV.F/HN could be used as a vector for passive immunisation against influenza and other respiratory pathogens.

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