Author: Pirola, Carlos J; Sookoian, Silvia
Title: PNPLA3 and COVID-19 outcomes: Thinking outside the box might explain the biology behind pleiotropic effects of rs738409 on the immune system. Cord-id: 2am0tm89 Document date: 2021_8_29
ID: 2am0tm89
Snippet: Genetic variants associated with the risk of NAFLD and NASH exhibit pleiotropic effects 1, 2 . Specifically, the nonsynonymous rs738409 C/G variant in PNPLA3 (patatin-like phospholipase domain-containing protein 3), which encodes I148M protein isoforms with a significant effect on the severity of several liver-related outcomes 3 , presents pleiotropic effects on cells that mediate the immune response 1, 2 . Figure 1 discloses the laboratory measurements and / or hematological traits associated w
Document: Genetic variants associated with the risk of NAFLD and NASH exhibit pleiotropic effects 1, 2 . Specifically, the nonsynonymous rs738409 C/G variant in PNPLA3 (patatin-like phospholipase domain-containing protein 3), which encodes I148M protein isoforms with a significant effect on the severity of several liver-related outcomes 3 , presents pleiotropic effects on cells that mediate the immune response 1, 2 . Figure 1 discloses the laboratory measurements and / or hematological traits associated with variants in PNPLA3 extracted from different data sources.
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