Author: Grabkowska-Drużyc, Magdalena; Balzarini, Jan; Piotrowska, Dorota G
Title: Design, synthesis, antiviral, and cytostatic evaluation of novel isoxazolidine analogues of C-nucleotides. Cord-id: 2oesc1go Document date: 2013_1_1
ID: 2oesc1go
Snippet: 5-Aryl-2-methylisoxazolidin-3-yl-3-phosphonates have been synthesised from N-methyl-C-diethoxyphosphorylnitrone and vinyl aryls in good yields. Isoxazolidine phosphonates obtained herein were evaluated for activity against a broad range of DNA and RNA viruses. None of the compounds were endowed with antiviral activity nor cytostatic activity at 100 to 250 μM concentrations.
Document: 5-Aryl-2-methylisoxazolidin-3-yl-3-phosphonates have been synthesised from N-methyl-C-diethoxyphosphorylnitrone and vinyl aryls in good yields. Isoxazolidine phosphonates obtained herein were evaluated for activity against a broad range of DNA and RNA viruses. None of the compounds were endowed with antiviral activity nor cytostatic activity at 100 to 250 μM concentrations.
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