Author: Laura Riva; Shuofeng Yuan; Xin Yin; Laura Martin-Sancho; Naoko Matsunaga; Sebastian Burgstaller-Muehlbacher; Lars Pache; Paul P. De Jesus; Mitchell V. Hull; Max Chang; Jasper Fuk-Woo Chan; Jianli Cao; Vincent Kwok-Man Poon; Kristina Herbert; Tu-Trinh Nguyen; Yuan Pu; Courtney Nguyen; Andrey Rubanov; Luis Martinez-Sobrido; Wen-Chun Liu; Lisa Miorin; Kris M. White; Jeffrey R. Johnson; Christopher Benner; Ren Sun; Peter G. Schultz; Andrew Su; Adolfo Garcia-Sastre; Arnab K. Chatterjee; Kwok-Yung Yuen; Sumit K. Chanda
Title: A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals Document date: 2020_4_17
ID: 1fgnfh62_40
Snippet: Although specific for each compound, therapeutic dose ranges are typically expected to track to cellular EC 50 s well below 1 µM concentrations. Therefore, we conducted a dose response analysis to determine the relationship between compound concentration and antiviral activity. Compound concentrations tested ranged from 1.1 nM to 2.5 µM in the immunofluorescence assay described previously. Total cell counts were used to assess compound cytotoxi.....
Document: Although specific for each compound, therapeutic dose ranges are typically expected to track to cellular EC 50 s well below 1 µM concentrations. Therefore, we conducted a dose response analysis to determine the relationship between compound concentration and antiviral activity. Compound concentrations tested ranged from 1.1 nM to 2.5 µM in the immunofluorescence assay described previously. Total cell counts were used to assess compound cytotoxicity ( Figure S4 ). In addition to remdesivir, treatment with 17 compounds resulted in discernable dose-dependent antiviral activities, most of which could be segregated based on broad functional, structural, or target-based classes (Figure 3A) . 10 of these known drugs have EC 50 s > 750 nM or values that could not be exactly extrapolated (Figures 3A and Figure S5 ), while 7 compounds harbored EC 50 s < 500 nM (6 of which reached > 80% author/funder. All rights reserved. No reuse allowed without permission.
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