Selected article for: "antiviral activity and broad spectrum"
Author: Zhao, Hanjun; Zhou, Jie; Zhang, Ke; Chu, Hin; Liu, Dabin; Poon, Vincent Kwok-Man; Chan, Chris Chung-Sing; Leung, Ho-Chuen; Fai, Ng; Lin, Yong-Ping; Zhang, Anna Jin-Xia; Jin, Dong-Yan; Yuen, Kwok-Yung; Zheng, Bo-Jian
Title: A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses
  • Cord-id: 4tx1pdxw
  • Document date: 2016_2_25
    • ID: 4tx1pdxw
    Snippet: A safe, potent and broad-spectrum antiviral is urgently needed to combat emerging respiratory viruses. In light of the broad antiviral activity of β-defensins, we tested the antiviral activity of 11 peptides derived from mouse β-defensin-4 and found that a short peptide, P9, exhibited potent and broad-spectrum antiviral effects against multiple respiratory viruses in vitro and in vivo, including influenza A virus H1N1, H3N2, H5N1, H7N7, H7N9, SARS-CoV and MERS-CoV. The antiviral activity of P9
    Document: A safe, potent and broad-spectrum antiviral is urgently needed to combat emerging respiratory viruses. In light of the broad antiviral activity of β-defensins, we tested the antiviral activity of 11 peptides derived from mouse β-defensin-4 and found that a short peptide, P9, exhibited potent and broad-spectrum antiviral effects against multiple respiratory viruses in vitro and in vivo, including influenza A virus H1N1, H3N2, H5N1, H7N7, H7N9, SARS-CoV and MERS-CoV. The antiviral activity of P9 was attributed to its high-affinity binding to viral glycoproteins, as well as the abundance of basic amino acids in its composition. After binding viral particles through viral surface glycoproteins, P9 entered into cells together with the viruses via endocytosis and prevented endosomal acidification, which blocked membrane fusion and subsequent viral RNA release. This study has paved the avenue for developing new prophylactic and therapeutic agents with broad-spectrum antiviral activities.

    Search related documents:
    Co phrase search for related documents
    • acidic environment and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7
    • acidic environment and low cytotoxicity: 1
    • acidic environment require and acute respiratory syndrome: 1
    • acidic residue and acute respiratory syndrome: 1
    • acidification inhibitor and acute respiratory syndrome: 1, 2
    • acidification prevent and acute respiratory syndrome: 1
    • acidification process and acute respiratory syndrome: 1
    • acute respiratory syndrome and live animals: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
    • acute respiratory syndrome and low cytotoxicity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • acute respiratory syndrome and low recovery: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • acute respiratory syndrome and low recovery rate: 1, 2