Engineering a Model to Study Viral Infections: Bioprinting, Microfluidics, and Organoids to Defeat Coronavirus Disease 2019 (COVID-19)

Shpichka, Anastasia; Bikmulina, Polina; Peshkova, Maria; Kosheleva, Nastasia; Zurina, Irina; Zahmatkesh, Ensieh; Khoshdel-Rad, Niloofar; Lipina, Marina; Golubeva, Elena; Butnaru, Denis; Svistunov, Andrei; Vosough, Massoud; Timashev, Peter

While the number of studies related to severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) is constantly growing, it is essential to provide a framework of modeling viral infections. Therefore, this review aims to describe the background presented by earlier used models for viral studies and an approach to design an “ideal” tissue model for SARS-CoV-2 infection. Due to the previous successful achievements in antiviral research and tissue engineering, combining the emerging techniques such as bioprinting, microfluidics, and organoid formation are considered to be one of the best approaches to form in vitro tissue models. The fabrication of an integrated multi-tissue bioprinted platform tailored for SARS-CoV-2 infection can be a great breakthrough that can help defeat coronavirus disease in 2019.