Author: Köksaldı, İlkay Çisil; Köse, Sıla; Ahan, Recep Erdem; Hacıosmanoğlu, Nedim; Şahin Kehribar, Ebru; Güngen, Murat Alp; Baştuğ, Aliye; Dinç, Bedia; Bodur, Hürrem; Özkul, Aykut; Şeker, Urartu Özgür Şafak
Title: SARS-CoV-2 Detection with De Novo-Designed Synthetic Riboregulators Cord-id: 4zitflqj Document date: 2021_6_30
ID: 4zitflqj
Snippet: [Image: see text] SARS-CoV-2 is a human pathogen and the main cause of COVID-19 disease, announced as a global pandemic by the World Health Organization. COVID-19 is characterized by severe conditions, and early diagnosis can make dramatic changes for both personal and public health. Low-cost, easy-to-use diagnostic capabilities can have a very critical role in controlling the transmission of the disease. Here, we are reporting a state-of-the-art diagnostic tool developed with an in vitro synthe
Document: [Image: see text] SARS-CoV-2 is a human pathogen and the main cause of COVID-19 disease, announced as a global pandemic by the World Health Organization. COVID-19 is characterized by severe conditions, and early diagnosis can make dramatic changes for both personal and public health. Low-cost, easy-to-use diagnostic capabilities can have a very critical role in controlling the transmission of the disease. Here, we are reporting a state-of-the-art diagnostic tool developed with an in vitro synthetic biology approach by employing engineered de novo riboregulators. Our design coupled with a home-made point-of-care device can detect and report the presence of SARS-CoV-2-specific genes. The presence of SARS-CoV-2-related genes triggers the translation of sfGFP mRNAs, resulting in a green fluorescence output. The approach proposed here has the potential of being a game changer in SARS-CoV-2 diagnostics by providing an easy-to-run, low-cost diagnostic capability.
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