Author: Laura Riva; Shuofeng Yuan; Xin Yin; Laura Martin-Sancho; Naoko Matsunaga; Sebastian Burgstaller-Muehlbacher; Lars Pache; Paul P. De Jesus; Mitchell V. Hull; Max Chang; Jasper Fuk-Woo Chan; Jianli Cao; Vincent Kwok-Man Poon; Kristina Herbert; Tu-Trinh Nguyen; Yuan Pu; Courtney Nguyen; Andrey Rubanov; Luis Martinez-Sobrido; Wen-Chun Liu; Lisa Miorin; Kris M. White; Jeffrey R. Johnson; Christopher Benner; Ren Sun; Peter G. Schultz; Andrew Su; Adolfo Garcia-Sastre; Arnab K. Chatterjee; Kwok-Yung Yuen; Sumit K. Chanda
Title: A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals Document date: 2020_4_17
ID: 1fgnfh62_59
Snippet: The concentration required for their antiviral activity could thus likely be difficult to reach in humans, without causing adverse effects. Taken together, confirmation of compounds with membership in enriched target classes underscore the importance of these molecular circuits in the regulation of SARS-CoV-2 replication and support the evaluation of additional preclinical and clinical stage molecules that target overrepresented mechanisms......
Document: The concentration required for their antiviral activity could thus likely be difficult to reach in humans, without causing adverse effects. Taken together, confirmation of compounds with membership in enriched target classes underscore the importance of these molecular circuits in the regulation of SARS-CoV-2 replication and support the evaluation of additional preclinical and clinical stage molecules that target overrepresented mechanisms.
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