Author: Taneri, Petek Eylul; Gómez-Ochoa, Sergio Alejandro; Llanaj, Erand; Raguindin, Peter Francis; Rojas, Lyda Z.; Roa-DÃaz, Zayne Milena; Salvador, Dante; Groothof, Dion; Minder, Beatrice; Kopp-Heim, Doris; Hautz, Wolf E.; Eisenga, Michele F.; Franco, Oscar H.; Glisic, Marija; Muka, Taulant
Title: Anemia and iron metabolism in COVID-19: a systematic review and meta-analysis Cord-id: 2gsl8jg5 Document date: 2020_8_20
ID: 2gsl8jg5
Snippet: Iron metabolism and anemia may play an important role in multiple organ dysfunction syndrome in Coronavirus disease 2019 (COVID-19). We conducted a systematic review and meta-analysis to evaluate biomarkers of anemia and iron metabolism (hemoglobin, ferritin, transferrin, soluble transferrin receptor, hepcidin, haptoglobin, unsaturated iron-binding capacity, erythropoietin, free erythrocyte protoporphyrine, and erythrocyte indices) in patients diagnosed with COVID-19, and explored their prognost
Document: Iron metabolism and anemia may play an important role in multiple organ dysfunction syndrome in Coronavirus disease 2019 (COVID-19). We conducted a systematic review and meta-analysis to evaluate biomarkers of anemia and iron metabolism (hemoglobin, ferritin, transferrin, soluble transferrin receptor, hepcidin, haptoglobin, unsaturated iron-binding capacity, erythropoietin, free erythrocyte protoporphyrine, and erythrocyte indices) in patients diagnosed with COVID-19, and explored their prognostic value. Six bibliographic databases were searched up to August 3rd 2020. We included 189 unique studies, with data from 57,563 COVID-19 patients. Pooled mean hemoglobin and ferritin levels in COVID-19 patients across all ages were 129.7 g/L (95% Confidence Interval (CI), 128.51; 130.88) and 777.33 ng/mL (95% CI, 701.33; 852.77), respectively. Hemoglobin levels were lower with older age, higher percentage of subjects with diabetes, hypertension and overall comorbidities, and admitted to intensive care. Ferritin level increased with older age, increasing proportion of hypertensive study participants, and increasing proportion of mortality. Compared to moderate cases, severe COVID-19 cases had lower hemoglobin [weighted mean difference (WMD), − 4.08 g/L (95% CI − 5.12; − 3.05)] and red blood cell count [WMD, − 0.16 × 10(12) /L (95% CI − 0.31; − 0.014)], and higher ferritin [WMD, − 473.25 ng/mL (95% CI 382.52; 563.98)] and red cell distribution width [WMD, 1.82% (95% CI 0.10; 3.55)]. A significant difference in mean ferritin levels of 606.37 ng/mL (95% CI 461.86; 750.88) was found between survivors and non-survivors, but not in hemoglobin levels. Future studies should explore the impact of iron metabolism and anemia in the pathophysiology, prognosis, and treatment of COVID-19. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10654-020-00678-5) contains supplementary material, which is available to authorized users.
Search related documents:
Co phrase search for related documents- abstract title and acute infection phase: 1
- abstract title and acute phase: 1, 2, 3, 4, 5, 6, 7
- abstract title and low mean difference: 1
- accurate picture and acute phase: 1
- acute ards distress respiratory syndrome and admission multiple organ dysfunction: 1
- acute ards distress respiratory syndrome and low efficacy: 1, 2
- acute ards distress respiratory syndrome and low hemoglobin: 1, 2
- acute ards distress respiratory syndrome and low hemoglobin level: 1
- acute ards distress respiratory syndrome and low mean difference: 1
- acute ards distress respiratory syndrome and lung gas volume: 1
- acute phase and admission multiple organ dysfunction: 1
- acute phase and low efficacy: 1, 2
- acute phase and low hemoglobin: 1
- acute phase reaction and low efficacy: 1
Co phrase search for related documents, hyperlinks ordered by date