Author: Chang, Calvin; Yan, Jerry; Yao, Zhicheng; Zhang, Chi; Li, Xiaowei; Mao, Haiâ€Quan
Title: Effects of Mesenchymal Stem Cellâ€Derived Paracrine Signals and Their Delivery Strategies Cord-id: 4xn1dafy Document date: 2021_1_12
ID: 4xn1dafy
Snippet: Mesenchymal stem cells (MSCs) have been widely studied as a versatile cell source for tissue regeneration and remodeling due to their potent bioactivity, which includes modulation of inflammation response, macrophage polarization toward proregenerative lineage, promotion of angiogenesis, and reduction in fibrosis. This review focuses on profiling the effects of paracrine signals of MSCs, commonly referred to as the secretome, and highlighting the various engineering approaches to tune the MSC se
Document: Mesenchymal stem cells (MSCs) have been widely studied as a versatile cell source for tissue regeneration and remodeling due to their potent bioactivity, which includes modulation of inflammation response, macrophage polarization toward proregenerative lineage, promotion of angiogenesis, and reduction in fibrosis. This review focuses on profiling the effects of paracrine signals of MSCs, commonly referred to as the secretome, and highlighting the various engineering approaches to tune the MSC secretome. Recent advances in biomaterialsâ€based therapeutic strategies for delivery of MSCs and MSCâ€derived secretome in the form of extracellular vesicles are discussed, along with their advantages and challenges.
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