Author: Chen, Cheng-Chang; Krüger, Jens; Sramala, Issara; Hsu, Hao-Jen; Henklein, Peter; Chen, Yi-Ming Arthur; Fischer, Wolfgang B.
Title: ORF8a of SARS-CoV forms an ion channel: Experiments and molecular dynamics simulations Cord-id: 7aw17jf8 Document date: 2010_8_12
ID: 7aw17jf8
Snippet: ORF8a protein is 39 residues long and contains a single transmembrane domain. The protein is synthesized using solid phase peptide synthesis and reconstituted into artificial lipid bilayers that forms cation-selective ion channels with a main conductance level of 8.9 ± 0.8 pS at elevated temperature (38.5 °C). Computational modeling studies including multi nanosecond molecular dynamics simulations in a hydrated POPC lipid bilayer are done with a 22 amino acid transmembrane helix to predict a p
Document: ORF8a protein is 39 residues long and contains a single transmembrane domain. The protein is synthesized using solid phase peptide synthesis and reconstituted into artificial lipid bilayers that forms cation-selective ion channels with a main conductance level of 8.9 ± 0.8 pS at elevated temperature (38.5 °C). Computational modeling studies including multi nanosecond molecular dynamics simulations in a hydrated POPC lipid bilayer are done with a 22 amino acid transmembrane helix to predict a putative homooligomeric helical bundle model. A structural model of a pentameric bundle is proposed with cysteines, serines and threonines facing the pore.
Search related documents:
Co phrase search for related documents- acute respiratory syndrome and low energy: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- acute respiratory syndrome and low energy pore: 1
- acute respiratory syndrome and lysine arginine: 1, 2, 3
- long range and low energy: 1, 2
Co phrase search for related documents, hyperlinks ordered by date