Selected article for: "bottleneck size and mutant virus"

Author: Sebastian J. Schreiber; Ruian Ke; Claude Loverdo; Miran Park; Priyanna Ahsan; James O. Lloyd-Smith
Title: Cross-scale dynamics and the evolutionary emergence of infectious diseases
  • Document date: 2016_7_29
  • ID: hain3be0_102
    Snippet: For x close to 0, we have the time at which the dynamics saturate, T e , is given approximately by Estimating the Probability of Emergence when α < 1. When α is less than 1, the frequency of mutant virus decrease in an infected host, and consequently, even if the adapted virus may emerge, the probability of emergence is very low, and even lower when the bottleneck size, N , increases. Here, we provide an approximation for the emergence probabil.....
    Document: For x close to 0, we have the time at which the dynamics saturate, T e , is given approximately by Estimating the Probability of Emergence when α < 1. When α is less than 1, the frequency of mutant virus decrease in an infected host, and consequently, even if the adapted virus may emerge, the probability of emergence is very low, and even lower when the bottleneck size, N , increases. Here, we provide an approximation for the emergence probability when α < 1, which explains why the probability of emergence decreases dramatically when N increases.

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