Author: Sebastian J. Schreiber; Ruian Ke; Claude Loverdo; Miran Park; Priyanna Ahsan; James O. Lloyd-Smith
Title: Cross-scale dynamics and the evolutionary emergence of infectious diseases Document date: 2016_7_29
ID: hain3be0_50
Snippet: Previous theoretical studies of evolutionary emergence of novel pathogens [12] [13] [14] [15] have assumed infected individuals are, at any point in time, infected primarily by a single pathogen strain. Consequently, shifts from infection with one strain to infection with another must occur abruptly, relative to other processes. Such abrupt shifts could correspond to within-host selective sweeps or, if mutant strains remain at low frequency, to r.....
Document: Previous theoretical studies of evolutionary emergence of novel pathogens [12] [13] [14] [15] have assumed infected individuals are, at any point in time, infected primarily by a single pathogen strain. Consequently, shifts from infection with one strain to infection with another must occur abruptly, relative to other processes. Such abrupt shifts could correspond to within-host selective sweeps or, if mutant strains remain at low frequency, to rare events in which only the mutant strain is transmitted. The seminal studies [12, 13] showed that under these conditions the probability of emergence is proportional to the frequency of these events, which they bundled together into a phenomenological "mutation rate".
Search related documents:
Co phrase search for related documents- emergence probability and infected individual: 1, 2, 3
- emergence probability and low frequency: 1
- emergence probability and mutant strain: 1, 2, 3, 4, 5, 6, 7
- emergence probability and mutant strain transmit: 1
- emergence probability and mutation rate: 1, 2
- emergence probability and novel pathogen: 1
- emergence probability and pathogen strain: 1
- event frequency and low frequency: 1, 2, 3
- evolutionary emergence and infected individual: 1, 2, 3, 4, 5, 6, 7
- evolutionary emergence and low frequency: 1
- evolutionary emergence and mutant strain: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- evolutionary emergence and mutant strain transmit: 1
- evolutionary emergence and mutation rate: 1, 2, 3, 4
- evolutionary emergence and novel pathogen: 1, 2, 3
- evolutionary emergence and pathogen strain: 1
- infected individual and low frequency: 1
- infected individual and mutant strain: 1, 2, 3, 4, 5, 6
- infected individual and mutation rate: 1, 2, 3, 4, 5
- infected individual and novel pathogen: 1, 2, 3
Co phrase search for related documents, hyperlinks ordered by date