Author: Korbinian Bösl; Aleksandr Ianevski; Thoa T. Than; Petter I. Andersen; Suvi Kuivanen; Mona Teppor; Eva Zusinaite; Uga Dumpis; Astra Vitkauskiene; Rebecca J. Cox; Hannimari Kallio-Kokko; Anders Bergqvist; Tanel Tenson; Valentyn Oksenych; Magnar Bjørås; Marit W. Anthonsen; David Shum; Mari Kaarbø; Olli Vapalahti; Marc P. Windisch; Giulio Superti-Furga; Berend Snijder; Denis Kainov; Richard K. Kandasamy
Title: Critical Nodes of Virus–Host Interaction Revealed Through an Integrated Network Analysis Document date: 2019_2_13
ID: ig6ul3u7_26
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/548909 doi: bioRxiv preprint The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/548909 doi: bioRxiv preprint Integrative analysis of host-virus interactome and RNAi data reveals COPI system as commonly targeted proviral process RNAi screens have been a powerful high-throughput method to identify .....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/548909 doi: bioRxiv preprint The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/548909 doi: bioRxiv preprint Integrative analysis of host-virus interactome and RNAi data reveals COPI system as commonly targeted proviral process RNAi screens have been a powerful high-throughput method to identify various cellular functions, including for identification of host restriction factors of viruses (Hirsch 2010) . In order to explore the functional relevance of the host targets in the hvPPI, we integrated it with five published RNAi screens that performed genome-wide or druggable-genome-wide RNAi screens for identifying host factors of HCV (Tai et al. 2009 ), HPV18 (Schmidt et al. 2013) , HPV16 (Aydin et al. 2014) , SV40 ) and VACV .
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