Author: Saunders, Kevin O.; Lee, Esther; Parks, Robert; Martinez, David R.; Li, Dapeng; Chen, Haiyan; Edwards, Robert J.; Gobeil, Sophie; Barr, Maggie; Mansouri, Katayoun; Alam, S. Munir; Sutherland, Laura L.; Cai, Fangping; Sanzone, Aja M.; Berry, Madison; Manne, Kartik; Kapingidza, Anyway B.; Azoitei, Mihai; Tse, Longping V.; Scobey, Trevor D.; Spreng, Rachel L.; Rountree, R. Wes; DeMarco, C. Todd; Denny, Thomas N.; Woods, Christopher W.; Petzold, Elizabeth W.; Oguin, Thomas H.; Sempowski, Gregory D.; Gagne, Matthew; Douek, Daniel C.; Tomai, Mark A.; Fox, Christopher B.; Seder, Robert; Wiehe, Kevin; Weissman, Drew; Pardi, Norbert; Acharya, Priyamvada; Andersen, Hanne; Lewis, Mark G.; Moore, Ian N.; Montefiori, David C.; Baric, Ralph S.; Haynes, Barton F.
Title: SARS-CoV-2 vaccination induces neutralizing antibodies against pandemic and pre-emergent SARS-related coronaviruses in monkeys Cord-id: 7pvphbt2 Document date: 2021_2_17
ID: 7pvphbt2
Snippet: Betacoronaviruses (betaCoVs) caused the severe acute respiratory syndrome (SARS) and Middle East Respiratory Syndrome (MERS) outbreaks, and now the SARS-CoV-2 pandemic. Vaccines that elicit protective immune responses against SARS-CoV-2 and betaCoVs circulating in animals have the potential to prevent future betaCoV pandemics. Here, we show that immunization of macaques with a multimeric SARS-CoV-2 receptor binding domain (RBD) nanoparticle adjuvanted with 3M-052-Alum elicited cross-neutralizing
Document: Betacoronaviruses (betaCoVs) caused the severe acute respiratory syndrome (SARS) and Middle East Respiratory Syndrome (MERS) outbreaks, and now the SARS-CoV-2 pandemic. Vaccines that elicit protective immune responses against SARS-CoV-2 and betaCoVs circulating in animals have the potential to prevent future betaCoV pandemics. Here, we show that immunization of macaques with a multimeric SARS-CoV-2 receptor binding domain (RBD) nanoparticle adjuvanted with 3M-052-Alum elicited cross-neutralizing antibody responses against SARS-CoV-1, SARS-CoV-2, batCoVs and the UK B.1.1.7 SARS-CoV-2 mutant virus. Nanoparticle vaccination resulted in a SARS-CoV-2 reciprocal geometric mean neutralization titer of 47,216, and robust protection against SARS-CoV-2 in macaque upper and lower respiratory tracts. Importantly, nucleoside-modified mRNA encoding a stabilized transmembrane spike or monomeric RBD protein also induced SARS-CoV-1 and batCoV cross-neutralizing antibodies, albeit at lower titers. These results demonstrate current mRNA vaccines may provide some protection from future zoonotic betaCoV outbreaks, and provide a platform for further development of pan-betaCoV nanoparticle vaccines.
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