Author: Araos, Joaquin; Alegria, Leyla; Garcia, Aline; Cruces, Pablo; Soto, Dagoberto; Erranz, BenjamÃn; Salomon, Tatiana; Medina, Tania; Garcia, Patricio; Dubó, Sebastián; Bachmann, MarÃa C.; Basoalto, Roque; Valenzuela, Emilio D.; Rovegno, Maximiliano; Vera, Magdalena; Retamal, Jaime; Cornejo, Rodrigo; Bugedo, Guillermo; Bruhn, Alejandro
Title: Effect of positive end-expiratory pressure on lung injury and haemodynamics during experimental acute respiratory distress syndrome treated with extracorporeal membrane oxygenation and near-apnoeic ventilation Cord-id: 004isps9 Document date: 2021_9_8
ID: 004isps9
Snippet: BACKGROUND: Lung rest has been recommended during extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS). Whether positive end-expiratory pressure (PEEP) confers lung protection during ECMO for severe ARDS is unclear. We compared the effects of three different PEEP levels whilst applying near-apnoeic ventilation in a model of severe ARDS treated with ECMO. METHODS: Acute respiratory distress syndrome was induced in anaesthetised adult male pigs by repeat
Document: BACKGROUND: Lung rest has been recommended during extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS). Whether positive end-expiratory pressure (PEEP) confers lung protection during ECMO for severe ARDS is unclear. We compared the effects of three different PEEP levels whilst applying near-apnoeic ventilation in a model of severe ARDS treated with ECMO. METHODS: Acute respiratory distress syndrome was induced in anaesthetised adult male pigs by repeated saline lavage and injurious ventilation for 1.5 h. After ECMO was commenced, the pigs received standardised near-apnoeic ventilation for 24 h to maintain similar driving pressures and were randomly assigned to PEEP of 0, 10, or 20 cm H(2)O (n=7 per group). Respiratory and haemodynamic data were collected throughout the study. Histological injury was assessed by a pathologist masked to PEEP allocation. Lung oedema was estimated by wet-to-dry-weight ratio. RESULTS: All pigs developed severe ARDS. Oxygenation on ECMO improved with PEEP of 10 or 20 cm H(2)O, but did not in pigs allocated to PEEP of 0 cm H(2)O. Haemodynamic collapse refractory to norepinephrine (n=4) and early death (n=3) occurred after PEEP 20 cm H(2)O. The severity of lung injury was lowest after PEEP of 10 cm H(2)O in both dependent and non-dependent lung regions, compared with PEEP of 0 or 20 cm H(2)O. A higher wet-to-dry-weight ratio, indicating worse lung injury, was observed with PEEP of 0 cm H(2)O. Histological assessment suggested that lung injury was minimised with PEEP of 10 cm H(2)O. CONCLUSIONS: During near-apnoeic ventilation and ECMO in experimental severe ARDS, 10 cm H(2)O PEEP minimised lung injury and improved gas exchange without compromising haemodynamic stability.
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