Selected article for: "cross scale conflict and host scale"
Author: Sebastian J. Schreiber; Ruian Ke; Claude Loverdo; Miran Park; Priyanna Ahsan; James O. Lloyd-Smith
Title: Cross-scale dynamics and the evolutionary emergence of infectious diseases
  • Document date: 2016_7_29
    • ID: hain3be0_55
    Snippet: Previous theoretical studies examining the evolutionary consequences of cross-scale conflict [e.g. 65, 72, 73] differ from ours in several ways. Notably, they consider longer-term evolution for endemic diseases using deterministic models, rather than the inherently stochastic, shorter-term dynamics of evolutionary emergence. Using multiscale endemic SIR models, Coombs et al. [73] found that pathogen strains competitively superior at the within-ho.....
    Document: Previous theoretical studies examining the evolutionary consequences of cross-scale conflict [e.g. 65, 72, 73] differ from ours in several ways. Notably, they consider longer-term evolution for endemic diseases using deterministic models, rather than the inherently stochastic, shorter-term dynamics of evolutionary emergence. Using multiscale endemic SIR models, Coombs et al. [73] found that pathogen strains competitively superior at the within-host scale could be displaced by competitively inferior strains that had higher reproductive numbers at the epidemiological scale. This phenomenon was driven by non-equilibrium within-host dynamics, where early fluctuations All rights reserved. No reuse allowed without permission.

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