Author: Khan, Haaris S; Nair, Vidhya R; Ruhl, Cody R; Alvarez-Arguedas, Samuel; Galvan Rendiz, Jorge L; Franco, Luis H; Huang, Linzhang; Shaul, Philip W; Kim, Jiwoong; Xie, Yang; Mitchell, Ron B; Shiloh, Michael U
Title: Identification of scavenger receptor B1 as the airway microfold cell receptor for Mycobacterium tuberculosis Cord-id: 86blkbdp Document date: 2020_3_5
ID: 86blkbdp
Snippet: Mycobacterium tuberculosis (Mtb) can enter the body through multiple routes, including via specialized transcytotic cells called microfold cells (M cell). However, the mechanistic basis for M cell entry remains undefined. Here, we show that M cell transcytosis depends on the Mtb Type VII secretion machine and its major virulence factor EsxA. We identify scavenger receptor B1 (SR-B1) as an EsxA receptor on airway M cells. SR-B1 is required for Mtb binding to and translocation across M cells in mo
Document: Mycobacterium tuberculosis (Mtb) can enter the body through multiple routes, including via specialized transcytotic cells called microfold cells (M cell). However, the mechanistic basis for M cell entry remains undefined. Here, we show that M cell transcytosis depends on the Mtb Type VII secretion machine and its major virulence factor EsxA. We identify scavenger receptor B1 (SR-B1) as an EsxA receptor on airway M cells. SR-B1 is required for Mtb binding to and translocation across M cells in mouse and human tissue. Together, our data demonstrate a previously undescribed role for Mtb EsxA in mucosal invasion and identify SR-B1 as the airway M cell receptor for Mtb.
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