Author: Valeria Lulla; Andrew E. Firth
Title: A hidden gene in astroviruses encodes a cell-permeabilizing protein involved in virus release Document date: 2019_6_6
ID: avq3zwmc_34
Snippet: In summary, using comparative genomic analyses we predicted a new gene in the Mamastrovirus genus; using ribosome profiling we demonstrated XP expression in HAstV1infected cells; and using a range of techniques we demonstrated the crucial role of XP in virus growth by promoting virus release, which is likely associated with its membranepermeabilizing activity. These findings add a new dimension to astrovirus molecular biology, with potential impa.....
Document: In summary, using comparative genomic analyses we predicted a new gene in the Mamastrovirus genus; using ribosome profiling we demonstrated XP expression in HAstV1infected cells; and using a range of techniques we demonstrated the crucial role of XP in virus growth by promoting virus release, which is likely associated with its membranepermeabilizing activity. These findings add a new dimension to astrovirus molecular biology, with potential impacts for new therapeutics (e.g. compounds that block XP activity) and vaccine development (e.g. by inhibiting XP expression).
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