Author: Rajanish Giri; Taniya Bhardwaj; Meenakshi Shegane; Bhuvaneshwari R. Gehi; Prateek Kumar; Kundlik Gadhave
Title: Dark Proteome of Newly Emerged SARS-CoV-2 in Comparison with Human and Bat Coronaviruses Document date: 2020_3_14
ID: n7ylgqfu_76
Snippet: Nsp3 is an almost 2,000-residue-long viral papain-like protease (PLP) that affects the phosphorylation and activation of IRF3 and therefore antagonizes the IFN pathway [130] . It was also demonstrated that Nsp3 works by stabilizing NF-inhibitor further blocking the NF-pathway [130] . Figure 21D represents the 1.85 Ã… resolution X-ray crystal structure of the catalytic core of Nsp3 protein from Human SARS CoV (PDB ID: 2FE8), which was obtained by .....
Document: Nsp3 is an almost 2,000-residue-long viral papain-like protease (PLP) that affects the phosphorylation and activation of IRF3 and therefore antagonizes the IFN pathway [130] . It was also demonstrated that Nsp3 works by stabilizing NF-inhibitor further blocking the NF-pathway [130] . Figure 21D represents the 1.85 Ã… resolution X-ray crystal structure of the catalytic core of Nsp3 protein from Human SARS CoV (PDB ID: 2FE8), which was obtained by Andrew and colleagues [131] . This structure consists of the residues 723-1036 of Nsp3. The structure revealed folds similar to a deubiquitinating enzyme in-vitro deubiquitinating activity of which was found to be efficiently high [131] .
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