Selected article for: "1ab replicase polyprotein and crucial role"
Author: Rajanish Giri; Taniya Bhardwaj; Meenakshi Shegane; Bhuvaneshwari R. Gehi; Prateek Kumar; Kundlik Gadhave
Title: Dark Proteome of Newly Emerged SARS-CoV-2 in Comparison with Human and Bat Coronaviruses
  • Document date: 2020_3_14
    • ID: n7ylgqfu_109
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.13.990598 doi: bioRxiv preprint analysed in this study definitely have multiple flexible regions. Importantly, our study provides novel information on presence of intrinsic disorder at the cleavage sites of the replicase 1ab polyprotein of CoVs. This observation confirms the crucial role of IDPRs in maturation of individual proteins. We a.....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.13.990598 doi: bioRxiv preprint analysed in this study definitely have multiple flexible regions. Importantly, our study provides novel information on presence of intrinsic disorder at the cleavage sites of the replicase 1ab polyprotein of CoVs. This observation confirms the crucial role of IDPRs in maturation of individual proteins. We also established that many of these proteins contain disorder-based binding motifs. Since IDPs/IDPRs might undergo structural transition upon association with their physiological partners, our study generates important grounds for better understanding of the functionality of these proteins, their interactions with other viral proteins, as well as interaction with host proteins in different physiological conditions. This will also guide structural biologists to carry out a structure-based analysis of SARS-CoV-2 proteome to explore the path for the development of new drugs and vaccines.

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