Author: Xiong, Yong; Liu, Yuan; Cao, Liu; Wang, Dehe; Guo, Ming; Jiang, Ao; Guo, Dong; Hu, Wenjia; Yang, Jiayi; Tang, Zhidong; Wu, Honglong; Lin, Yongquan; Zhang, Meiyuan; Zhang, Qi; Shi, Mang; Liu, Yingle; Zhou, Yu; Lan, Ke; Chen, Yu
Title: Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients Cord-id: 0daf0i75 Document date: 2020_3_31
ID: 0daf0i75
Snippet: Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of host immune response for this fatal disease. To characterize the transcriptional signatures of host inflammatory response to SARS-CoV-2 (HCoV-19) infection, we carried out transcriptome sequencing of the
Document: Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of host immune response for this fatal disease. To characterize the transcriptional signatures of host inflammatory response to SARS-CoV-2 (HCoV-19) infection, we carried out transcriptome sequencing of the RNAs isolated from the bronchoalveolar lavage fluid (BALF) and peripheral blood mononuclear cells (PBMC) specimens of COVID-19 patients. Our results reveal distinct host inflammatory cytokine profiles to SARS-CoV-2 infection in patients, and highlight the association between COVID-19 pathogenesis and excessive cytokine release such as CCL2/MCP-1, CXCL10/IP-10, CCL3/MIP-1A, and CCL4/MIP1B. Furthermore, SARS-CoV-2 induced activation of apoptosis and P53 signalling pathway in lymphocytes may be the cause of patients’ lymphopenia. The transcriptome dataset of COVID-19 patients would be a valuable resource for clinical guidance on anti-inflammatory medication and understanding the molecular mechansims of host response.
Search related documents:
Co phrase search for related documents- acute ards respiratory distress syndrome and local anesthesia: 1
- acute ards respiratory distress syndrome and local tissue: 1, 2, 3
- acute ards respiratory distress syndrome and lung biopsy: 1, 2, 3, 4, 5, 6, 7, 8
- acute ards respiratory distress syndrome and lung disease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute ards respiratory distress syndrome and lung epithelial cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- acute ards respiratory distress syndrome and lung inflammation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute ards respiratory distress syndrome and lung inflammation suppress: 1
- acute ards respiratory distress syndrome and lung injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute inflammatory response and lung biopsy: 1
- acute inflammatory response and lung disease: 1, 2, 3, 4, 5
- acute inflammatory response and lung epithelial cell: 1
- acute inflammatory response and lung inflammation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- acute inflammatory response and lung injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute kidney injury and local anesthesia: 1
- acute kidney injury and local tissue: 1, 2
- acute kidney injury and lung biopsy: 1, 2
- acute kidney injury and lung disease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
- acute kidney injury and lung inflammation: 1, 2, 3, 4, 5, 6, 7, 8
- acute kidney injury and lung injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
Co phrase search for related documents, hyperlinks ordered by date