Author: Grossegesse, Marica; Hartkopf, Felix; Nitsche, Andreas; Schaade, Lars; Doellinger, Joerg; Muth, Thilo
Title: Perspective on Proteomics for Virus Detection in Clinical Samples Cord-id: 001njzrs Document date: 2020_10_22
ID: 001njzrs
Snippet: [Image: see text] One of the most widely used methods to detect an acute viral infection in clinical specimens is diagnostic real-time polymerase chain reaction. However, because of the COVID-19 pandemic, mass-spectrometry-based proteomics is currently being discussed as a potential diagnostic method for viral infections. Because proteomics is not yet applied in routine virus diagnostics, here we discuss its potential to detect viral infections. Apart from theoretical considerations, the current
Document: [Image: see text] One of the most widely used methods to detect an acute viral infection in clinical specimens is diagnostic real-time polymerase chain reaction. However, because of the COVID-19 pandemic, mass-spectrometry-based proteomics is currently being discussed as a potential diagnostic method for viral infections. Because proteomics is not yet applied in routine virus diagnostics, here we discuss its potential to detect viral infections. Apart from theoretical considerations, the current status and technical limitations are considered. Finally, the challenges that have to be overcome to establish proteomics in routine virus diagnostics are highlighted.
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