Dark Proteome of Newly Emerged SARS-CoV-2 in Comparison with Human and Bat Coronaviruses

Rajanish Giri; Taniya Bhardwaj; Meenakshi Shegane; Bhuvaneshwari R. Gehi; Prateek Kumar; Kundlik Gadhave

The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.13.990598 doi: bioRxiv preprint profiles of ORF14 of SARS-CoV-2, Human SARS CoV, and Bat CoV. Although these proteins have calculated mean PPID values of 0.00%, 2.86%, and 0.00% respectively, Figure 16 shows that they have flexible N-and C-terminal regions. This protein can use intrinsic disorder or structural flexibility for protein-protein interactions since it possesses MoRFs. It mainly contains MoRFs at N-and C-terminal regions as tabulated in (Table 2 , Supplementary Table 7 and 8) . It was also found to contain several RNA and DNA binding residues (Supplementary Table 9, 10, and 11) . These results indicating its vital role in protein function related to molecular recognition such as protein-protein, protein-RNA, and Protein-DNA interaction.