Author: A. Sina Booeshaghi; Lior Pachter
Title: Decrease in ACE2 mRNA expression in aged mouse lung Document date: 2020_4_5
ID: 0pocrjvk_5
Snippet: In a comparison of the 3-month old and 24-month old mice, we found significantly fewer cells with ACE2 expression in the 24-month old mice (2.1 fold reduction, p = 0.0375, Figure 1b) . We corroborated this result with an analysis of three bulk RNA-seq samples from 3-month old mice and three bulk RNA-seq samples from 22-month old mice (1.5 fold reduction, p = 0.0163, Supp. Fig. 2 ). This reduction in ACE2 mRNA expression is also seen in an analysi.....
Document: In a comparison of the 3-month old and 24-month old mice, we found significantly fewer cells with ACE2 expression in the 24-month old mice (2.1 fold reduction, p = 0.0375, Figure 1b) . We corroborated this result with an analysis of three bulk RNA-seq samples from 3-month old mice and three bulk RNA-seq samples from 22-month old mice (1.5 fold reduction, p = 0.0163, Supp. Fig. 2 ). This reduction in ACE2 mRNA expression is also seen in an analysis of FACS sorted alveolar macrophage bulk RNA-seq samples (2.7 fold reduction, p = 0.3076, Supp. Fig 3) . These results are consistent with a previously observed dramatic reduction of ACE2 protein between 3-month old and 24-month old rat lungs 8 .
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