Author: Siying Ye; Chris Cowled; Cheng-Hon Yap; John Stambas
Title: Deep sequencing of primary human lung epithelial cells challenged with H5N1 influenza virus reveals a proviral role for CEACAM1 Document date: 2018_5_17
ID: 6arj2i3m_22
Snippet: Through HiSeq analysis, we identified the cell adhesion molecule CEACAM1 as a critical regulator of 294 immunity. Knockdown of endogenous CEACAM1 not only reduced H5N1-stimulated inflammatory 295 cytokine/chemokine production but also inhibited virus replication. 296 H5N1 infection resulted in significant upregulation of a number of inflammatory 297 cytokines/chemokines genes, including AXL and STING, which were significantly reduced by 298 apocy.....
Document: Through HiSeq analysis, we identified the cell adhesion molecule CEACAM1 as a critical regulator of 294 immunity. Knockdown of endogenous CEACAM1 not only reduced H5N1-stimulated inflammatory 295 cytokine/chemokine production but also inhibited virus replication. 296 H5N1 infection resulted in significant upregulation of a number of inflammatory 297 cytokines/chemokines genes, including AXL and STING, which were significantly reduced by 298 apocynin treatment to a level lower than that observed in uninfected cells (Table S4 ). It has been 299 previously demonstrated that treatment of PR8 H1N1-infected mice with anti-AXL antibody 300 significantly reduces lung inflammation and virus titers (38). STING has been shown to be important 301 All rights reserved. No reuse allowed without permission.
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