Author: Siying Ye; Chris Cowled; Cheng-Hon Yap; John Stambas
Title: Deep sequencing of primary human lung epithelial cells challenged with H5N1 influenza virus reveals a proviral role for CEACAM1 Document date: 2018_5_17
ID: 6arj2i3m_5
Snippet: While the impact of influenza virus infection has been relatively well studied in animal models 61 (8, 9) , the human cellular responses are poorly defined due to the lack of available human autopsy 62 material, especially from HPAI virus-infected patients. In the present study, we characterized influenza 63 virus infection of primary human alveolar epithelial type II (ATII) cells isolated from normal human 64 lung tissue donated by patients unde.....
Document: While the impact of influenza virus infection has been relatively well studied in animal models 61 (8, 9) , the human cellular responses are poorly defined due to the lack of available human autopsy 62 material, especially from HPAI virus-infected patients. In the present study, we characterized influenza 63 virus infection of primary human alveolar epithelial type II (ATII) cells isolated from normal human 64 lung tissue donated by patients undergoing lung resection. ATII cells are a physiologically relevant 65 infection model as they are a major target for influenza A viruses when entering the respiratory tract 66 (10). Human host gene expression following HPAI H5N1 virus (A/Chicken/Vietnam/0008/04) 67 infection of primary ATII cells was analyzed using Illumina HiSeq deep sequencing. In order to gain a 68 better understanding of the mechanisms underlying modulation of host immunity in an anti-69 inflammatory environment, we also analyzed changes in gene expression following HPAI H5N1 70 infection in the presence of the reactive oxygen species inhibitor (ROS), apocynin, a compound known 71 to interfere with NADPH oxidase subunit assembly (5, 6). 72
Search related documents:
Co phrase search for related documents- animal model and deep sequencing: 1, 2
- animal model and epithelial type: 1, 2, 3, 4, 5
- animal model and gene expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- animal model and host immunity: 1, 2, 3, 4, 5
- animal model and human cellular response: 1
- animal model and human host: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- animal model and infection model: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- animal model and inflammatory environment: 1
- animal model and influenza virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- animal model and influenza virus infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- ATII cell and epithelial type: 1, 2, 3
- ATII cell and influenza virus: 1, 2
- cellular response and human cellular response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- cellular response and human host: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- cellular response and human host gene: 1
- cellular response and human host gene expression: 1
- cellular response and infection model: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
- cellular response and inflammatory environment: 1, 2, 3
- cellular response and influenza virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
Co phrase search for related documents, hyperlinks ordered by date