Author: Hammerschmidt, Stefan Josef; Müller, Patrick; Schirmeister, Tanja
Title: SARS-CoV-PL(pro)-Inhibitoren als mögliche Breitspektrum-Virostatika Cord-id: 0c0j934f Document date: 2021_5_11
ID: 0c0j934f
Snippet: The SARS-CoV-encoded papain-like cysteine protease (PL(pro)) plays crucial roles in viral replication and maturation processes. It is required to cleave the precursor polyproteins into functional proteins. Thus, it is considered to be a promising target for developing specific drugs. For rational optimization of hit compounds, information about the structure-activity relationship (SAR) is fundamental. Herein, we characterize isoindolines as a new class of PL(pro) inhibitors.
Document: The SARS-CoV-encoded papain-like cysteine protease (PL(pro)) plays crucial roles in viral replication and maturation processes. It is required to cleave the precursor polyproteins into functional proteins. Thus, it is considered to be a promising target for developing specific drugs. For rational optimization of hit compounds, information about the structure-activity relationship (SAR) is fundamental. Herein, we characterize isoindolines as a new class of PL(pro) inhibitors.
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