Delayed-Phase Thrombocytopenia in Patients of Coronavirus Disease 2019 (COVID-19)

Hao Zhou; Wanxin Chen; Ziping Li; Bohan Yang; Qiong Zhou; Ping Wang; Jianhua Zhu; Xuexing Chen; Peng Yang

The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.11.20059170 doi: medRxiv preprint delayed phase, without evidence of other coagulation abnormalities. The pathology results from each of the three patients shared common features: (1) bone marrow showed no obvious abnormities in the myeloid or the erythroid cells; (2) number of atypical or reactive lymphocytes increased; (3) maturation of megakaryocyte was impaired, the mature platelet-producing megakaryocyte were rare, and most megakaryocytes were immature granular megakaryocytes. Two patients' bone marrow smear images were presented in Figure 3 . In Figure 3E , the mature platelet-producing megakaryocyte was attached by three platelets (one large and the other two small). This might suggest body compensate by making abnormally large platelets.