Selected article for: "high throughput and rna sequencing"
Author: Engen, Phillip A.; Naqib, Ankur; Jennings, Cheryl; Green, Stefan J.; Landay, Alan; Keshavarzian, Ali; Voigt, Robin M.
Title: Nasopharyngeal Microbiota in SARS-CoV-2 Positive and Negative Patients
  • Cord-id: 0e2e95g5
  • Document date: 2021_6_1
    • ID: 0e2e95g5
    Snippet: We investigated nasopharyngeal microbial community structure in COVID-19-positive and -negative patients. High-throughput 16S ribosomal RNA gene amplicon sequencing revealed significant microbial community structure differences between COVID-19-positive and -negative patients. This proof-of-concept study demonstrates that: (1) nasopharyngeal microbiome communities can be assessed using collection samples already collected for SARS-CoV-2 testing (viral transport media) and (2) SARS-CoV-2 infectio
    Document: We investigated nasopharyngeal microbial community structure in COVID-19-positive and -negative patients. High-throughput 16S ribosomal RNA gene amplicon sequencing revealed significant microbial community structure differences between COVID-19-positive and -negative patients. This proof-of-concept study demonstrates that: (1) nasopharyngeal microbiome communities can be assessed using collection samples already collected for SARS-CoV-2 testing (viral transport media) and (2) SARS-CoV-2 infection is associated with altered dysbiotic microbial profiles which could be a biomarker for disease progression and prognosis in SARS-CoV-2. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12575-021-00148-6.

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