Author: A. Sina Booeshaghi; Lior Pachter
Title: Decrease in ACE2 mRNA expression in aged mouse lung Document date: 2020_4_5
ID: 0pocrjvk_1
Snippet: The severity of illness resulting from infection with SARS-CoV-2 virus 1 is strongly correlated with age 2 . There has been much speculation about the mechanisms underlying this strong association, with one hypothesis being that age-related changes in ACE2 , a crucial receptor used by SARS-CoV-2 to enter cells 3 , affect disease susceptibility 4 . Nevertheless, there has been little data on the age dependence of ACE2 expression in humans, with th.....
Document: The severity of illness resulting from infection with SARS-CoV-2 virus 1 is strongly correlated with age 2 . There has been much speculation about the mechanisms underlying this strong association, with one hypothesis being that age-related changes in ACE2 , a crucial receptor used by SARS-CoV-2 to enter cells 3 , affect disease susceptibility 4 . Nevertheless, there has been little data on the age dependence of ACE2 expression in humans, with the exception of GTEx data, which is limited in the age range to adults 5 .
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