Selected article for: "affinity receptor and high affinity"
Author: Abdullah, Shatha F.; Sharquie, Inas K.
Title: SARS-CoV-2: A Piece of Bad News
  • Cord-id: 0znypao7
  • Document date: 2020_6_30
    • ID: 0znypao7
    Snippet: A shocking third species emerged from a family of coronaviruses (CoV) in late 2019 following viruses causing SARS (Severe Acute Respiratory Syndrome-CoV) in 2003 and MERS (Middle East Respiratory Syndrome-CoV) in 2012; it’s a novel coronavirus now called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; formerly called 2019-nCoV). First emerging in China, it has spread rapidly across the globe, giving rise to significant social and economic costs and imposing severe strain on health
    Document: A shocking third species emerged from a family of coronaviruses (CoV) in late 2019 following viruses causing SARS (Severe Acute Respiratory Syndrome-CoV) in 2003 and MERS (Middle East Respiratory Syndrome-CoV) in 2012; it’s a novel coronavirus now called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; formerly called 2019-nCoV). First emerging in China, it has spread rapidly across the globe, giving rise to significant social and economic costs and imposing severe strain on healthcare systems. Since many attempts to control viral spread has been futile, the only old practice of containment including city lockdown and social distancing are working to some extent. Unfortunately, specific antiviral drugs and vaccines remain unavailable yet. Many factors are encountered to play essential roles in viral pathogenesis. These include a broad viral-host range with high receptor binding affinity to various human tissues, viral adaptation to humans, a high percentage of asymptomatic but infected carriers, prolonged incubation, and viral shedding periods. There are also a wide variety of pulmonary and extrapul-monary tissue damage mechanisms including direct cell injury or immune-mediated damages involving the immune cells, upregulation of proinflammatory cytokines, and antibody dependent enhancement that can result in multi-organ failure. In this article, we summarise some evidence on the various steps in SARS-CoV-2 pathogenesis and immune evasion strategies to assess their contribution to our understanding of unresolved problems related to SARS-CoV-2 prevention, control, and treatment protocols.

    Search related documents:
    Co phrase search for related documents
    • acute phase and ade hypothesis: 1
    • acute phase and low respiratory: 1
    • acute phase and lung epithelium: 1, 2
    • acute phase and lung tissue: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
    • acute phase and lymphocyte apoptosis: 1
    • acute phase and macrophage activation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • acute phase and macrophage activation syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • low respiratory and lung tissue: 1, 2, 3, 4, 5, 6, 7
    • low respiratory tract and lung tissue: 1, 2
    • lung tissue and lymph liver: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • lung tissue and lymphocyte apoptosis: 1
    • lung tissue and macrophage activation: 1, 2, 3, 4, 5, 6, 7, 8
    • lung tissue and macrophage activation syndrome: 1, 2, 3
    • lymph liver and macrophage activation: 1, 2
    • lymph liver and macrophage activation syndrome: 1, 2
    • lymphocyte apoptosis and mab neutralizing monoclonal antibody: 1