Author: Rajanish Giri; Taniya Bhardwaj; Meenakshi Shegane; Bhuvaneshwari R. Gehi; Prateek Kumar; Kundlik Gadhave
Title: Dark Proteome of Newly Emerged SARS-CoV-2 in Comparison with Human and Bat Coronaviruses Document date: 2020_3_14
ID: n7ylgqfu_87
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.13.990598 doi: bioRxiv preprint RDRP-nsp8-nsp7 complex bound to the Nsp12. The structure identified conserved neutral Nsp7 and Nsp8 binding sites overlapping with finger and thumb domains on Nsp12 of the virus [144] . We found that Nsp7 of SARS-CoV-2 share 100% sequence identity with Nsp7 of Bat CoV and 98.80% with Nsp7 from Human SARS (F.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.13.990598 doi: bioRxiv preprint RDRP-nsp8-nsp7 complex bound to the Nsp12. The structure identified conserved neutral Nsp7 and Nsp8 binding sites overlapping with finger and thumb domains on Nsp12 of the virus [144] . We found that Nsp7 of SARS-CoV-2 share 100% sequence identity with Nsp7 of Bat CoV and 98.80% with Nsp7 from Human SARS (Figure 25E) , while SARS-CoV-2 Nsp8 is closer to Nsp8 of Human SARS (97.47%) than to Nsp8 of Bat CoV (96.46%) (Figure 26D ). author/funder. All rights reserved. No reuse allowed without permission.
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